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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described by their focus on practical aspects of designing a study which include recruitment and consent, adherence and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from various geographical areas. This type of heterogeneity which is vital for pragmatic trials to be reliable and lessen the chance of bias is also essential. A high degree of heterogeneity, however can result in problems with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually requested by practitioners and policy makers to inform their decision making. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a practical trial that include recruitment, design and delivery of the intervention, as well as the follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline query that used the words naturalistic and 프라그마틱 슬롯 하는법 pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatism. It is important to note that the majority of studies were conducted in primary-care settings.